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Antiandrogenic Effects of Topically Applied Spironolactone on the Hamster Flank Organ
Arthur Weissmann, MD;
Jeffrey Bowden, MD;
Beryn L. Frank;
Stephen N. Horwitz, MD;
Phillip Frost, MD
Arch Dermatol. 1985;121(1):57-62.
Abstract
• The effects of topically applied spironolactone on the sebaceous glands of flank organs in adult male golden hamsters were investigated. Daily treatment with spironolactone (0.3 mg and 3 mg) on one side only significantly reduced the size of the treated flank organs, while the contralateral flank organs remained unchanged. Lower doses of spironolactone and the vehicle had no effect. Cyproterone acetate therapy resulted in the bilateral reduction of flank organ sizes. In vivo measurement of the palpable bulk of the flank organs correlated with flank organ volumes as determined by computer-assisted planimetry of serial histologic sections. Dry weights of seminal vesicles in animals treated with spironolactone did not differ significantly from those of the control group, while topically applied cyproterone acetate significantly reduced seminal vesicle weight. Topically administered spironolactone appears to have only local antiandrogenic effects, as indicated by the lack of changes in the untreated contralateral flank organs and in the weights of seminal vesicles.
(Arch Dermatol 1985;121:57-62)
Author Affiliations
From the Departments of Dermatology (Drs Weissmann, Bowden, Horwitz, and Frost) and Pathology (Ms Frank), Mount Sinai Medical Center, Miami Beach, Fla.
Footnotes
Accepted for publication Feb 22, 1984.
Presented at the Joint International Meeting of the Society for Investigative Dermatology and the European Society for Dermatological Research, Washington, DC, April 27-May 1, 1983.
Reprint requests to the Department of Dermatology, Mount Sinai Medical Center, 4300 Alton Rd, Miami Beach, FL 33140 (Dr Weissmann).
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