This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (55)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Yukie Niwa, MD, PhD; Tsuyoshi Sakane, MD; Masao Shingu, MD; Ichiro Yanagida, MD; Jinro Komura, MD; Yoshiki Miyachi, MD

Arch Dermatol. 1985;121(1):73-78.

Abstract
• To examine the possible correlation between tissue injury and neutrophil-produced active oxygens (AOs) in patients with linear IgA bullous dermatosis (BD), we studied the capacity of neutrophils from six patients with BD to generate AOs. Cultured endothelial cells from human umbilical-cord vein were also incubated with the patients' neutrophils to assess AO-induced tissue injury. The AO production by patients' neutrophils was significantly elevated. The patients' neutrophils, as well as those from healthy controls preincubated with patients' serum, produced significantly increased levels of cytotoxic response on coincubation with chromium 51-labeled human endothelial cells. These results suggest that the tissue damage observed in BD may be partially due to both excessive production of AOs by neutrophils and a serum factor present in the patients, and further postulate the similar pathogenic process in dermatitis herpetiformis.

(Arch Dermatol 1985;121:73-78)

Author Affiliations
From the Department of Internal Medicine, Shimane Medical University, Izumo, Japan (Drs Niwa and Sakane); the Department of Internal Medicine, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan (Dr Shingu); the Department of Dermatology, Kansai Medical University, Osaka, Japan (Drs Yanagida and Komura); and the Department of Dermatology, Kyoto University, Kyoto, Japan (Dr Miyachi).

Footnotes
Accepted for publication March 2, 1984.

Reprint requests to Niwa Institute for Immunology, 4-4, Asahimachi, Tosashimizu, Kochi-ken, 787-03, Japan (Dr Niwa).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Chronic bullous disease of childhood and a paecilomyces lung infection in chronic granulomatous disease
Smitt et al.
Arch. Dis. Child. 1997;77:150-152.
ABSTRACT | FULL TEXT  

Abnormalities in Serum Lipids and Leukocyte Superoxide Dismutase and Associated Cataract Formation in Patients With Atopic Dermatitis
Niwa and Iizawa
Arch Dermatol 1994;130:1387-1392.
ABSTRACT