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Noel Weidner, MD; David J. Flanders, MD; Peter R. Jochimsen, MD; Fred W. Stamler, MD

Arch Dermatol. 1985;121(10):1302-1306.

Abstract
• We report a case of neuroid giant congenital melanocytic nevus (GCMN) in which a malignant schwannomalike tumor developed. Literature review reveals that neurosarcomatous differentiation occurs among malignant tumors arising in GCMNs, apparently with greater incidence in those GCMNs showing benign neuroid differentiation. Although the differences between neuroid melanocytes and Schwann's cells may be more conceptual than real, we believe that the current tumor arising within a melanocytic nevus is likely of neuroid melanocytic origin and best designated as neurosarcomatous malignant melanoma.

(Arch Dermatol 1985;121:1302-1306)

Author Affiliations
From the Departments of Pathology (Drs Weidner, Flanders, and Stamler) and Surgery (Dr Jochimsen), University of Iowa Hospitals and Clinics, Iowa City. Dr Weidner is now with the Department of Pathology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC.

Footnotes
Accepted for publication March 22, 1985.

Reprint requests to Department of Pathology, Bowman Gray School of Medicine, 300 S Hawthorne Rd, Winston-Salem, NC 27103 (Dr Weidner).

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