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Richard K. Scher, MD; Douglas W. K. Tom, MD; Edward V. Lally, MD; Hendrik A. Bogaars, MD

Arch Dermatol. 1985;121(11):1406-1409.

Abstract
• In vivo capillary microscopic findings and proximal nail fold biopsy specimens from 19 patients with various connective tissue diseases, idiopathic Raynaud's phenomenon, and non-connective tissue diseases were studied. Periodic acid-Schiff-positive serous cuticular deposits were not specific to the group of patients with connective tissue disease. Generally, the severity of deposits correlated with the severity of the in vivo capillary microscopic pattern but not with disease severity or duration. The finding of these cuticular deposits may help to identify those patients with idiopathic Raynaud's phenomenon who are at risk to develop a connective tissue disease.

(Arch Dermatol 1985;121:1406-1409)

Author Affiliations
From the Department of Medicine, Divisions of Dermatology (Drs Scher and Tom) and Rheumatology (Dr Lally), and the Department of Pathology (Dr Bogaars), Brown University School of Medicine, Roger Williams General Hospital, and Providence Veterans Administration Medical Center, Providence, RI.

Footnotes
Accepted for publication July 11, 1985.

Presented in part by Dr Scher at the American Academy of Dermatology Hair and Nail Symposium, Washington, DC, Dec 2, 1984, and by Dr Lally at the American Rheumatism Association Annual Scientific Meeting, Anaheim, Calif, June 7, 1985.

Reprint requests to Brown University Program in Medicine, 825 Chalkstone Ave, Providence, RI 02908 (Dr Scher).

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