This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (9)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Herschel S. Zackheim, MD; Ervin H. Epstein, Jr, MD; William R. Crain, MD

Arch Dermatol. 1985;121(11):1410-1414.

Abstract
• Seven patients with lymphomatoid papulosis were treated with solutions of topical carmustine, a nitrosourea compound. Recently used schedules have employed 10 mg of carmustine in dilute alcohol applied to the total skin surface daily for four to 17 weeks (total dosage, 280 to 1,180 mg). All patients experienced a rapid reduction in the number and size of lesions. Maintenance therapy consisted of local applications of carmustine (2 to 4 mg/mL of 95% ethanol) to individual new papules. This method was effective in suppressing disease activity and reduced by half the average life cycle of individual lesions. However, long-term lesion-free remissions were not seen. Bone marrow depression did not occur.

(Arch Dermatol 1985;121:1410-1414)

Author Affiliations
From the Department of Dermatology, University of California, School of Medicine, San Francisco.

Footnotes
Accepted for publication June 28, 1985.

Reprint requests to 133 Arch St, Redwood City, CA 94062 (Dr Zackheim).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Lymphomatoid Papulosis Followed by Hodgkin's Lymphoma: Differential Response to Therapy
Zackheim et al.
Arch Dermatol 1993;129:86-91.
ABSTRACT