This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (48)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Philip H. Cooper, MD; Henry F. Frierson, Jr, MD; A. Glenn Morrison, MD

Arch Dermatol. 1985;121(11):1445-1448.

Abstract
• Two patients are described in whom malignant transformation occurred within an eccrine spiradenoma. Their findings were compared with those of six similar patients from the literature, and a characteristic clinicopathologic picture was evident. The typical history was one of rapid enlargement of a cutaneous nodule of long standing. The neoplasms were composed, at least in part, of large, markedly atypical basaloid cells with numerous mitotic figures. Adjacent benign spiradenoma was observed microscopically in each case, and some of the carcinomas retained architectural features reminiscent of spiradenoma. One patient died of disseminated tumor, but follow-up was short or lacking in several cases. Malignant transformation of eccrine spiradenoma shares many clinical and pathologic features with malignant transformation of dermal cylindroma.

(Arch Dermatol 1985;121:1445-1448)

Author Affiliations
From the Departments of Pathology (Drs Cooper and Frierson) and Dermatology (Dr Cooper), University of Virginia, Charlottesville; and the Department of Pathology, Rockingham Memorial Hospital, Harrisonburg, Va (Dr Morrison).

Footnotes
Accepted for publication April 2, 1985.

Reprint requests to Department of Pathology, Box 214, University of Virginia Medical Center, Charlottesville, VA 22908 (Dr Cooper).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?