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Darab Kamanabroo, MD; Wolfgang Schmitz-Landgraf, MD; Beate M. Czarnetzki, MD

Arch Dermatol. 1985;121(12):1548-1549.

Abstract
• Five patients with severe drug-induced toxic epidermal necrolysis improved rapidly after one to two plasma exchanges. The improvement of all five patients treated with plasmapheresis contrasts with the disease's mortality rate of up to 50%, as reported in the literature and as observed among our previously treated patients. Since there is no effective treatment for toxic epidermal necrolysis, a controlled clinical trial to evaluate the effectiveness of plasma exchange would seem worthwhile.

(Arch Dermatol 1985;121:1548-1549)

Author Affiliations
From the Departments of Internal Medicine (Drs Kamanabroo and Schmitz-Landgraf) and Dermatology (Dr Czarnetzki), University Clinics, Münster, West Germany.

Footnotes
Accepted for publication June 7, 1985.

Reprint requests to Universitäts-Hautklinik, Von-Esmarch-Str 56, D-4400 Münster, West Germany (Dr Czarnetzki).

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