This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Vincent Falanga, MD; Thomas A. Medsger, MD; Morris Reichlin, MD

Arch Dermatol. 1985;121(3):345-347.

Abstract
• Seven patients with severe linear scleroderma were initially found to have antibodies to double-stranded DNA (dsDNA) in higher titers, using the Farr technique. These patients, however, lacked the systemic involvement normally accompanying such antibodies. A detailed investigation of their sera using Crithidia luciliae assay and single-stranded DNA (ssDNA) labeled with iodine 131 disclosed high titers of antibodies to ssDNA and absent dsDNA antibodies. The ssDNA antibody titer was considerably higher than the mean for unselected patients with systemic lupus erythematosus. It is possible that these antibodies define a subgroup of patients with linear scleroderma who have more severe and extensive involvement of skin and underlying tissues.

(Arch Dermatol 1985;121:345-347)

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Localized scleroderma is an autoimmune disorder
Takehara and Sato
Rheumatology (Oxford) 2005;44:274-279.
ABSTRACT | FULL TEXT  

Antigen Specificity of Antihistone Antibodies in Localized Scleroderma
Sato et al.
Arch Dermatol 1994;130:1273-1277.
ABSTRACT  

Prevalence and Characteristics of Anti--Single-Stranded DNA Antibodies in Localized Scleroderma: Comparison With Systemic Lupus Erythematosus
Ruffatti et al.
Arch Dermatol 1991;127:1180-1183.
ABSTRACT  

Anti-Single-Stranded DNA Antibody and Muscle Involvement in Localized Scleroderma
Takehara et al.
Arch Dermatol 1990;126:1368-1369.
ABSTRACT  

Antinuclear and Anti-Single-Stranded DNA Antibodies in Morphea and Generalized Morphea
Falanga et al.
Arch Dermatol 1987;123:350-353.
ABSTRACT  

Linear Scleroderma: Clinical Spectrum, Prognosis, and Laboratory Abnormalities
FALANGA et al.
ANN INTERN MED 1986;104:849-857.
ABSTRACT  

Immunologic Abnormalities in Linear Scleroderma
Vazquez et al.
Arch Dermatol 1986;122:623-624.
ABSTRACT  

Hereditary Deficiency of C2 in Association With Linear Scleroderma `En Coup de Sabre'
Hulsmans et al.
Arch Dermatol 1986;122:76-79.
ABSTRACT  

Juvenile Linear Scleroderma Associated With Serologic Abnormalities
Woo and Rasmussen
Arch Dermatol 1985;121:1403-1405.
ABSTRACT