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Clinical, Histologic, and Cell Kinetic Discriminants Between Lamellar Ichthyosis and Nonbullous Congenital Ichthyosiform Erythroderma
Michael Hazell, MB, MRCP;
Ronald Marks, MB, FRCP, MRCPath
Arch Dermatol. 1985;121(4):489-493.
Abstract
• Patients described as having lamellar ichthyosis (LI) may not all have the same disorder. We studied nine patients, four of whom had erythroderma and generalized fine scaling, while the remainder had more marked scaling and hyperkeratosis without erythema. The former group is referred to as having nonbullous congenital ichthyosiform erythroderma (CIE), and the other is said to have LI. The clinical differences were paralleled by cell kinetic and histologic differences. The mean tritiated thymidine autoradiographic labeling indices were 9.36 ± 4.05 and 19.70 ± 5.84 for the LI and CIE groups, respectively. The histologic differences were delineated using 10-cm analogue scales and showed statistically significant differences for hyperkeratosis and parakeratosis. These data support the hypothesis that LI and CIE are separate disorders.
(Arch Dermatol 1985;121:489-493)
Author Affiliations
From the Department of Medicine, University of Wales College of Medicine, Heath Park, Cardiff.
Footnotes
Accepted for publication Nov 13, 1984.
Reprint requests to the Department of Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, Wales (Dr Marks).
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