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Thiazide Diuretic Therapy and Chronic Photosensitivity
Howard N. Robinson, MD;
Warwick L. Morison, MD;
Antoinette F. Hood, MD
Arch Dermatol. 1985;121(4):522-524.
Abstract
• Chronic photosensitivity associated with hydrochlorothiazide ingestion occurred in four patients. These patients developed a debilitating photosensitivity that persisted for months to years even after they stopped taking the diuretic. Their age range was 44 to 66 years. Phototesting with ultraviolet B (UV-B) and ultraviolet A (UV-A) radiation revealed decreased minimal erythemal doses for one or both wave bands in all patients tested. Histologic examination of skin biopsy specimens from the patients' UV-B and UV-A test sites and lesional skin revealed an acute eczematous dermatitis. Treatment with methoxsalen and UV-A radiation successfully cleared the photosensitive eruption in the patients.
(Arch Dermatol 1985;121:522-524)
Author Affiliations
From the Department of Dermatology, The Johns Hopkins Medical Institutions, Baltimore.
Footnotes
Accepted for publication Oct 24, 1984.
Reprint requests to Department of Dermatology, The Johns Hopkins Medical Institutions, 600 N Wolfe St, Baltimore, MD 21205 (Dr Morison).
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