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Quinidine Photosensitivity
Robert B. Armstrong, MD;
Eileen E. Leach, RN;
Gail Whitman, MD;
Leonard C. Harber, MD;
Maureen B. Poh-Fitzpatrick, MD
Arch Dermatol. 1985;121(4):525-528.
Abstract
• A 55-year-old woman developed a dermatitis confined to light-exposed areas while taking quinidine gluconate, warfarin sodium, furosemide, spironolactone, and digoxin after cardiac surgery. Phototesting indicated a normal erythematous response to 290- to 320-nm ultraviolet radiation, but she developed erythema from 6 joules/sq cm of 320- to 400-nm radiation (ultraviolet A [UV-A]), a much lower dose than needed to produce a reaction in normal individuals. Two days after she discontinued quinidine and warfarin, phototesting showed no reaction to as much as 20 joules/sq cm of UV-A. One week after resuming quinidine (but not warfarin), she again reacted to 8 joules/sq cm of UV-A. No reactivity was elicited when the preparation was applied to the skin or injected into the dermis either with or without subsequent UV-A irradiation.
(Arch Dermatol 1985;121:525-528)
Author Affiliations
From the Department of Dermatology, Columbia-Presbyterian Medical Center, New York.
Footnotes
Accepted for publication Sept 17, 1984.
Reprint requests to Department of Dermatology, Columbia-Presbyterian Medical Center, 630 W 168th St, New York, NY 10032 (Dr Armstrong).
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