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A Study With Antibody to S-100 Protein

R. K. Winkelmann, MD, PhD; Margot S. Peters, MD

Arch Dermatol. 1985;121(6):753-755.

Abstract
• Fourteen biopsy specimens from ten patients with atypical fibroxanthoma were studied with the peroxidase-antiperoxidase method for binding of S-100 antibody. Six specimens from four patients were minimally positive. The S-100-positive cells were observed in greatest concentrations at the periphery of the lesions and were associated with perivascular inflammatory cells. By this method, it appears that there is not a Langerhans' cell type of atypical fibroxanthoma. The S-100 antibody can help differentiate desmoplastic juvenile melanoma and malignant melanoma from atypical fibroxanthoma.

(Arch Dermatol 1985;121:753-755)

Author Affiliations
From the Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minn.

Footnotes
Accepted for publication Dec 19, 1984.

Reprints not available.

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