This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Presence of Human Papillomavirus (HPV) Structural Antigens and of HPV 16-Related DNA Sequences

Gerd Gross, MD; Manfred Hagedorn, MD; Hans Ikenberg, MD; Theodor Rufli, MD; Catherine Dahlet, MD; Edouard Grosshans, MD; Lutz Gissmann, PhD

Arch Dermatol. 1985;121(7):858-863.

Abstract
This study reviews 39 cases of anogenital bowenoid papulosis lesions in 22 individuals of both sexes that were analyzed clinically, histologically, immunocytochemically, and virologically. Macroscopically, three different types of lesions were demonstrated: erythematous macules; papules (lichenoid and/or pigmented papules); and leukoplakialike lesions. Microscopically, bowenoid papulosis fulfills the criteria of a squamous cell carcinoma in situ. Much like oral precancers, three distinct growth patterns (flat, endophytic, and exophytic) could be differentiated, which did not correlate with the clinical aspect of the lesions. In only two (5.12%) of the 39 cases of bowenoid papulosis could structural antigens of papillomaviruses be detected immunocytochemically (peroxidase-antiperoxidase technique). The DNA from 12 lesions that were analyzed for the presence of papillomavirusspecific sequences hybridized stringently in all cases with the human papillomavirus 16 specific DNA probe labeled with phosphorus 32.

(Arch Dermatol 1985;121:858-863)

Author Affiliations
From the Departments of Dermatology, University of Freiburg, Federal Republic of Germany (FRG) (Drs Gross and Hagedorn); University of Strasbourg, France (Drs Dahlet and Grosshans); University of Basel, Switzerland (Dr Rufli); and Deutsche Krebsforschungszentrum, Heidelberg, FRG (Drs Gissmann and Ikenberg).

Footnotes
Accepted for publication Dec 31, 1984.

Reprint requests to Department of Dermatology, University of Freiburg, Haupstr 7, D-7800, Freiburg, FRG (Dr Gross).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

European course on HPV associated pathology: guidelines for primary care physicians for the diagnosis and management of anogenital warts
von Krogh et al.
Sex. Transm. Infect. 2000;76:162-168.
ABSTRACT | FULL TEXT  

Bowen's Disease of the Nail Bed and Periungual Area: A Clinicopathologic Analysis of Seven Cases
Sau et al.
Arch Dermatol 1994;130:204-209.
ABSTRACT  

Immunosuppression in Men With Bowenoid Papulosis
Feldman et al.
Arch Dermatol 1989;125:651-654.
ABSTRACT  

Human Papillomavirus: Current Concepts
Androphy
Arch Dermatol 1989;125:683-685.
ABSTRACT  

Human Papillomavirus Type 16 in Bowenoid Papulosis, Intraoral Papillomas, and Squamous Cell Carcinoma of the Tongue
Lookingbill et al.
Arch Dermatol 1987;123:363-368.
ABSTRACT  

Successful Treatment of Condylomata Acuminata and Bowenoid Papulosis With Subcutaneous Injections of Low-Dose Recombinant Interferon-{alpha}
Gross et al.
Arch Dermatol 1986;122:749-750.
ABSTRACT