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IgE Antibodies to Staphylococcus aureusPrevalence in Patients With Atopic Dermatitis
Stephen J. Friedman, MD;
Arnold L. Schroeter, MD;
Henry A. Homburger, MD
Arch Dermatol. 1985;121(7):869-872.
Abstract
• We determined the prevalence of IgE antibodies to Staphylococcus aureus by optimized immunoradiometric assay methods in serum specimens from 69 patients with atopic dermatitis. All patients had positive aerobic cultures for S aureus from skin. Significant binding attributable to IgE antibodies was noted in three of 25 patients with atopic dermatitis and superimposed impetiginization or pustules, but antibodies were not detected in the remaining 44 patients whose lesions were colonized with S aureus. By comparison, IgE antibodies to S aureus were uniformly present in high titer in serum samples from patients with the hyperimmunoglobulin E syndrome. We conclude that most patients with atopic dermatitis do not have detectable levels of IgE antibodies to S aureus.
(Arch Dermatol 1985;121:869-872)
Author Affiliations
From the Department of Dermatology (Drs Friedman and Schroeter) and the Section of Clinical Immunology (Dr Homburger), Mayo Clinic, Rochester, Minn.
Footnotes
Accepted for publication Dec 5, 1984.
Presented at the fall meeting of the Midwest Section of the American Federation for Clinical Research, Chicago, Nov 1, 1984.
Reprint requests to Section of Clinical Immunology, 160 Hilton Bldg, Mayo Clinic, Rochester, MN 55905 (Dr Homburger).
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