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Reduction of Antibody-Dependent Cell-Mediated Cytotoxicity of Polymorphonuclear Leukocytes

Charles N. Ellis, MD; Sewon Kang, MPH; Roy C. Grekin, MD; Albert F. LoBuglio, MD; John J. Voorhees, MD

Arch Dermatol. 1985;121(7):877-880.

Abstract
• We monitored the antibody-dependent cell-mediated cytotoxicity of polymorphonuclear leukocytes from 14 patients with psoriasis before and during etretinate therapy. Neutrophils obtained from the patients with psoriasis at pretherapy demonstrated significantly greater cytotoxic activity than control cells. After four weeks of etretinate therapy, the cytotoxicity of neutrophils from the psoriatic patients decreased significantly and was no longer significantly different from the control value (at a 1:1 effector-to-target ratio). The decline in neutrophil cytotoxicity preceded significant clearing of our patients' psoriasis. The reduction in the antibody-dependent cell-mediated cytotoxicity of polymorphonuclear leukocytes from patients with psoriasis occurs early during therapy and may represent one of the mechanisms of action of etretinate.

(Arch Dermatol 1985;121:877-880)

Author Affiliations
From the Clinical Pharmacology Unit, Department of Dermatology (Drs Ellis, Grekin, and Voorhees and Mr Kang), and Department of Internal Medicine (Dr LoBuglio), University of Michigan Medical Center, and Dermatology Service, Veterans Administration Medical Center (Drs Ellis, Grekin, and Voorhees), Ann Arbor. Dr LoBuglio is now with the Comprehensive Cancer Care Center, University of Alabama, Birmingham.

Footnotes
Accepted for publication Feb 20, 1985.

Read in part before the National Clinical Dermatology Conference, Chicago, June 26, 1983.

Reprint requests to Dermatology Service (110), Veterans Administration Medical Center, 2215 Fuller Rd, Ann Arbor, MI 48105 (Dr Ellis).

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