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Modulation of Clinical Course of Psoriatic Subjects

Vincent A. Ziboh, PhD; Kenneth A. Cohen, MD; Charles N. Ellis, MD; Craig Miller; Ted A. Hamilton, MS; Knud Kragballe, MD, PhD; Constance R. Hydrick, MS; John J. Voorhees, MD

Arch Dermatol. 1986;122(11):1277-1282.

Abstract
Findings from an eight-week fish oil-supplemented diet given to 13 psoriatic patients demonstrated that eicosapentaenoic acid (20:5,n3 [EPA]) and docosahexaenoic acid (22:6,n3 [DCHA]) are rapidly incorporated into the sera, neutrophils, and epidermis of participating patients, and that the incorporation of EPA and DCHA into epidermal lipids increased with weeks of supplementation with minimal alteration of arachidonic acid (AA) in the epidermal lipids. Global clinical evaluation showed that eight patients demonstrated mild to moderate improvement in their psoriatic lesions. Improved clinical response correlated with high EPA/DCHA ratios attained in epidermal tissue specimens. These findings underscore the need for further investigations into the role of dietary n3 fatty acids, particularly the possibility of pentaenoic acid as a potential protective agent and/or therapeutic adjunct for the clinical management of psoriasis.

(Arch Dermatol 1986;122:1277-1282)

Author Affiliations
From the Department of Dermatology, School of Medicine, University of California, Davis (Dr Ziboh and Mr Miller); the Department of Dermatology, University of Michigan Medical School (Drs Cohen, Ellis, Kragballe, and Voorhees and Mr Hamilton); the Dermatology Service, Veterans Administration Medical Center, Ann Arbor (Dr Ellis); and the Clinical Research Center, University of Michigan Hospital, Ann Arbor (Ms Hydrick).

Footnotes
Accepted for publication June 27, 1986.

Presented in part at the Joint International Meeting of the United States and Japanese Societies of Investigative Dermatology, Washington, DC, May 1-5, 1985.

Reprint requests to Department of Dermatology, TB 192, School of Medicine, University of California, Davis, CA 95616 (Dr Ziboh).

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