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Irene E. Kochevar, PhD; Warwick L. Morison, MD; Joel L. Lamm, MD; Daniel J. McAuliffe; Andre Western, PhD; A. F. Hood, MD

Arch Dermatol. 1986;122(11):1283-1287.

Abstract
The therapeutic use of piroxicam as a nonsteroidal anti-inflammatory agent is associated with the development of photosensitivity in less than 1% of patients. The eruption usually occurs within a few days of commencing treatment with the medication. This time course suggests a phototoxic reaction. Attempts to demonstrate the phototoxic effects of piroxicam in humans, laboratory animals, and in in vitro cell assays were unsuccessful. At high concentration, however, one metabolite of piroxicam was phototoxic in animal studies and in in vitro assays. A second metabolite was mildly phototoxic in laboratory animals. These results suggest a mechanism whereby piroxicam photosensitivity may be due to a metabolite preferentially formed or accumulated in affected patients.

(Arch Dermatol 1986;122:1283-1287)

Author Affiliations
From the Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston (Drs Kochevar and Western and Mr McAuliffe); the Department of Dermatology, The Johns Hopkins University, Baltimore (Drs Morison, Lamm, and Hood), and the National Cancer Institute-Frederick Cancer Research Facility, Frederick, Md (Dr Morison).

Footnotes
Accepted for publication June 4, 1986.

The contents of this publication do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US government.

Reprint requests to Wellman Laboratories, Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114 (Dr Kochevar).

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