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Aditya K. Gupta, MD; Carl J. Cardella, MD, FRCP(C); Herbert F. Haberman, MD, FRCP(C)

Arch Dermatol. 1986;122(11):1288-1293.

Abstract
• There is an increased risk of developing cutaneous neoplasms in patients with renal transplants who are receiving immunosuppressive therapy. We studied 523 consecutive white patients who had received renal transplants at a Canadian medical center. Malignant neoplasms developed in 7.5% of these patients, and 72% of these neoplasms were cutaneous in origin. Compared with the general population, the rate of development of all skin cancers, squamous cell carcinoma, and basal cell carcinoma was 3.2, 18.4, and 1.4 times, respectively. In our study the squamous cell carcinoma to basal cell carcinoma ratio was 2.3:1, compared with 0.2:1 in the general population. There was no significant difference in the site of development of skin cancer in patients with renal transplants compared with the general population. There was, however, a propensity for the development of multiple skin cancers at an earlier age, especially on sun-exposed areas. The results of this study have been compared with those of other world medical centers.

(Arch Dermatol 1986;122:1288-1293)

Author Affiliations
From the Divisions of Dermatology (Drs Gupta and Haberman) and Nephrology (Dr Cardella), Department of Medicine, Toronto Western Hospital, University of Toronto. Dr Gupta is now with the University of Michigan Medical School, Ann Arbor.

Footnotes
Accepted for publication June 25, 1986.

Read in part before the American Academy of Dermatology meeting, June 26, 1986, Boston.

Reprint requests to Division of Dermatology, Cavell Wing, Toronto Western Hospital, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8 (Dr Haberman).

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