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A Syndrome of Peculiar Multiple Skin Eruptions, Generalized Lymphadenopathy, and Polyclonal Hypergammaglobulinemia

Shinchi Watanabe, MD; Kuniaki Ohara, MD; Atsushi Kukita, MD; Shigeo Mori, MD

Arch Dermatol. 1986;122(11):1314-1320.

Abstract
• A description is given of two patients with peculiar multiple skin eruptions, asymptomatic generalized lymphadenopathy, and polyclonal hypergammaglobulinemia. Both patients were admitted to our hospital for further evaluation of an increased erythrocyte sedimentation rate and hypergammaglobulinemia discovered during routine medical examinations. Despite various investigations, the underlying disease causing the hypergammaglobulinemia was not found. Histologic examination disclosed dense perivascular infiltration of plasma cells in the dermis. In the lymph nodes, considerable plasma cell infiltration was found from the cortex to the medulla. These plasma cells were mature and showed no cellular atypism. The association of peculiar multiple skin eruptions, lymphadenopathy, and polyclonal hypergammaglobulinemia, which we have called "systemic plasmacytosis," signifies a new syndrome that can be differentiated from diseases reported previously.

(Arch Dermatol 1986;122:1314-1320)

Author Affiliations
From the Department of Dermatology (Drs Watanabe, Ohara, and Kukita) and Pathology (Dr Mori), Faculty of Medicine, University of Tokyo.

Footnotes
Accepted for publication March 5, 1986.

Read in part before the 16th International Congress of Dermatology, Tokyo, May 28, 1982.

Reprint requests to Department of Dermatology, Faculty of Medicine, University of Tokyo, 3-1, 7-chome Hongo Bunkyo-ku, Tokyo, Japan (Dr Watanabe).

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