This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (11)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Kohdo Yoshikuni, MD; Hachiro Tagami, MD; Mizuho Yamada, MD; Kayoko Sudo, PhD; Takashi Kanno, MD

Arch Dermatol. 1986;122(12):1420-1424.

Abstract
• Peculiar erythematosquamous lesions were observed in two adult patients in Japan with hereditary lactate dehydrogenase M-subunit deficiency. Although these patients showed excessive fatigue and myoglobulinuria after extended exercise, they were usually asymptomatic. However, nonpruritic follicular papules or erythematous patches with scaly edges were present on the extensor surfaces of the extremities of these patients since childhood, showing some improvement after puberty. There were also erythematous patches on the weight-bearing areas of their soles. These patches showed exacerbation and a tendency toward peripheral spreading in summer. These skin lesions provide an important clue in the detection of this genetic enzyme deficiency.

(Arch Dermatol 1986;122:1420-1424)

Author Affiliations
From the Department of Dermatology, Shizuoka City Hospital, Shizuoka, Japan (Dr Yoshikuni); Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan (Dr Tagami); and the Departments of Dermatology (Dr Yamada) and Laboratory Medicine (Drs Sudo and Kanno), Hamamatsu (Japan) University School of Medicine.

Footnotes
Accepted for publication April 2, 1986.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?