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Erythrokeratodermia Variabilis Treated With IsotretinoinA Clinical, Histologic, and Ultrastructural Study
I. Paul Rappaport, MD;
Jeffry A. Goldes, MD;
Robert W. Goltz, MD
Arch Dermatol. 1986;122(4):441-445.
Abstract
• A 30-year-old woman with erythrokeratodermia variabilis was treated with oral isotretinoin for four months. Clinical and light and electron microscopic observations were made before and after treatment. A characteristic electron microscopic feature was subnormal numbers of keratinosomes within the stratum granulosum of hyperkeratotic plaques. Isotretinoin therapy resulted in almost complete clinical clearing of these plaques and restoration of normal numbers of epidermal keratinosomes. In addition, distinctive dyskeratotic cells containing clumped tonofilaments were observed within the stratum granulosum by electron microscopy. These cells persisted after retinoid treatment.
(Arch Dermatol 1986;122:441-445)
Author Affiliations
From the Department of Dermatology, University of Minnesota, Minneapolis. Dr Rappaport is now in private practice, Norwalk, Conn; Dr Goldes is with Malcolm Grow Medical Center, Andrews Air Force Base, Camp Springs, Md; and Dr Goltz is with the University of California at San Diego Medical Center.
Footnotes
Accepted for publication Dec 20, 1985.
Presented as a poster at the 22nd annual meeting of the American Society of Dermatopathology, Washington, DC, Nov 29-30, 1984, and read before the 43rd annual meeting of the American Academy of Dermatology, Washington, DC, Dec 1, 1984.
Reprint requests to 10 Mott Ave, Norwalk, CT 06850 (Dr Rappaport).
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