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A Double-blind Study

Thomas A. Giustina, MD; Jeffery C. B. Stewart, DDS, MS; Charles N. Ellis, MD; Joseph A. Regezi, DDS, MS; Thomas Annesley, PhD; Thomas Y. Woo, MD; John J. Voorhees, MD

Arch Dermatol. 1986;122(5):534-536.

Abstract
• In a double-blind study, 20 patients with oral lichen planus were treated twice daily with 0.1% isotretinoin gel or the vehicle alone for two months. Subsequently, patients who used the placebo received the active preparation for another two months. Patients treated with the active medication displayed significantly greater improvement than patients receiving the placebo. Patients who were treated initially with the placebo showed statistically significant improvement after receiving the topical isotretinoin treatment for two months. Side effects from using the gel were primarily a transient burning sensation or irritation on initial application.

(Arch Dermatol 1986;122:534-536)

Author Affiliations
From the Clinical Dermatopharmacology Unit of the Department of Dermatology (Drs Giustina, Ellis, Woo, and Voorhees) and the Department of Pathology (Drs Regezi and Annesley), University of Michigan Medical Center; the Dermatology Service, Veterans Administration Medical Center (Dr Ellis); and the Department of Oral Pathology, University of Michigan School of Dentistry (Drs Stewart and Regezi), Ann Arbor, Mich.

Footnotes
Accepted for publication Feb 3, 1986.

Reprint requests to the Dermatology Service (110), Veterans Administration Medical Center, 2215 Fuller Rd, Ann Arbor, MI 48105 (Dr Ellis).

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