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Intermittent Pulse Dosing for Extended Maintenance Treatment of Psoriasis

H. Irving Katz, MD; Ngo T. Hien, MD; Steven E. Prawer, MD; Jack C. Scott, MD; Elaine M. Grivna, LPN

Arch Dermatol. 1987;123(10):1308-1311.

Abstract
• A study was done of extended maintenance therapy using either betamethasone dipropionate (Diprolene) in optimized vehicle (OV) (ointment) or placebo in patients with psoriasis vulgaris. Of 59 patients originally enrolled in the study, 38 assessable patients achieved clearing of at least 85% improvement from baseline with traditional betamethasone in OV twice a day for two to three weeks before intermittent pulse dosing was attempted. Thereafter, the test medication was used on weekends (three consecutive doses at 12-hour intervals) once a week. Fourteen patients (74%) of the betamethasone in OV group and four patients (21%) of the placebo group maintained a remission status for 12 weeks. Intermittent pulse dosing with betamethasone in OV seems safe and efficacious maintenance therapy in selected psoriatic patients.

(Arch Dermatol 1987;123:1308-1311)

Author Affiliations
From the Department of Dermatology, Minnesota Clinical Study Center, Fridley.

Footnotes
Accepted for publication April 24, 1987.

Read in part before the 29th annual meeting of the Noah Worcester Dermatological Society, Marco Island, Fla, March 1, 1986.

Reprint requests to Minnesota Clinical Study Center, 250 Unity Professional Bldg, 500 Osborne Rd NE, Fridley, MN 55432 (Dr Katz).

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