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Luz Sison-Fonacier, MD; Jean-Claude Bystryn, MD

Arch Dermatol. 1987;123(11):1507-1510.

Abstract
• The immunologic specificity of pemphigus vulgaris (PV) antigens was studied by serologic analysis. Serum samples of 19 patients with PV antibodies were tested for reactivity with seven specimens of normal human skin by indirect immunofluorescence. Some PV antibodies reacted to antigens expressed in all specimens of skin, while others reacted to antigens expressed in only some specimens of skin. This was not due to differences in the titer of PV antibodies among serum samples or to regional variation or individual-to-individual fluctuations in the expression of a single PV antigen. The patterns of cross-reactivity suggest that PV antigens are heterogeneous. Two different groups can be defined serologically: (1) a "major" (PV) antigen expressed in all individuals, antibodies to which are the most common in PV; (2) a family of "minor" PV antigens whose expression varies from individual to individual. Several immunologically distinct PV antigens are expressed concurrently in the same specimen of skin.

(Arch Dermatol 1987;123:1507-1510)

Author Affiliations
From the Department of Dermatology, New York University School of Medicine.

Footnotes
Accepted for publication May 13, 1987.

Read before the annual meeting of the Society of Investigative Dermatology, Washington, DC, May 2, 1986.

Reprint requests to Department of Dermatology, New York University School of Medicine, 560 First Ave, New York, NY 10016 (Dr Bystryn).

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