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Presence of Human Papillomavirus 16 DNA in Tumor Tissue

Mary Seabury Stone, MD; Christine A. Noonan, PhD; Jaime Tschen, MD; Suzanne Bruce, MD

Arch Dermatol. 1987;123(11):1517-1520.

Abstract
• A 36-year-old black man with bilateral squamous cell carcinoma in situ of the feet is described. The DNA hybridization analysis performed on the tumor tissue demonstrated the presence of human papillomavirus 16 DNA. Human papillomavirus 16 has been detected repeatedly in genital carcinomas, and evidence is mounting that it may play an important role in the development of malignancy.

(Arch Dermatol 1987;123:1517-1520)

Author Affiliations
From the Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City (Dr Stone), and the Departments of Virology and Epidemiology (Dr Noonan), Dermatology (Drs Tschen and Bruce), and Pathology (Dr Tschen), Baylor College of Medicine, Houston.

Footnotes
Accepted for publication June 17, 1987.

Reprint requests to the Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242 (Dr Stone).

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