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Scleredema and ParaproteinemiaEnhanced Collagen Production and Elevated Type I Procollagen Messenger RNA Level in Fibroblasts Grown From Cultures From the Fibrotic Skin of a Patient
Aarne Oikarinen, MD, PhD;
Leena Ala-Kokko, MD;
Riitta Palatsi, MD;
Leena Peltonen, MD, PhD;
Jouni Uitto, MD, PhD
Arch Dermatol. 1987;123(2):226-229.
Abstract
• An edematous rash developed on the abdominal skin of a 76-year-old woman who had had diabetes mellitus for ten years. Some months later, the affected skin became thickened and indurated. Histopathologic examination revealed marked dermal fibrosis with excessive deposition of collagen. The patient also had IgA ( -type) paraproteinemia. Fibroblast cultures from the affected and unaffected skin were studied for collagen metabolism. Procollagen synthesis was elevated about sixfold on fibroblasts derived from the affected skin. A similar increase was detected in messenger RNA (mRNA) levels using a complementary DNA clone specific for human pro 1(1) collagen mRNA. The elevated mRNA level could be the result of increased transcriptional activity of collagen genes or decreased degradation of collagen mRNAs. Our findings suggest that increased collagen deposition may account for the marked dermal fibrosis that we observed in this patient.
(Arch Dermatol 1987;123:226-229)
Author Affiliations
From the Departments of Dermatology (Drs Oikarinen and Palatsi), Medical Biochemistry (Dr Ala-Kokko), and Anatomy (Dr Peltonen), and Collagen Research Unit, University of Oulu, Finland; and the Department of Medicine, UCLA School of Medicine, and the Division of Dermatology, Harbor-UCLA Medical Center, Torrance, Calif (Dr Uitto).
Footnotes
Accepted for publication June 2, 1986.
Reprint requests to Department of Dermatology, Oulu University Central Hospital, SF-90220 Oulu, Finland (Dr Oikarinen).
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