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Charles N. Ellis, MD; Sewon Kang, MPH; Aaron I. Vinik, MD; Roy C. Grekin, MD; William J. Cunningham, MD; John J. Voorhees, MD

Arch Dermatol. 1987;123(4):471-475.

Abstract
• Since lipemia is commonly induced by retinoid therapy, we investigated the effects of etretinate administration on glucose metabolism by obtaining five-hour oral glucose tolerance tests in 23 patients before and after 20 weeks of etretinate therapy for psoriasis. Compared with pretreatment values, peak and aggregate levels for serum glucose and aggregate levels for serum insulin were significantly lower during therapy. The changes were not associated with obesity, weight loss during treatment, or pretherapy glucose tolerance or insulin secretion level. Of 11 patients with impaired or diabetic glucose tolerance prior to therapy, eight patients had improved glucose tolerance after 20 weeks of etretinate treatment. Despite inducing hypertriglyceridemia in most patients, etretinate therapy is associated with a reduction in glucose levels in response to a glucose load.

(Arch Dermatol 1987;123:471-475)

Author Affiliations
From the Department of Dermatology (Drs Ellis, Grekin, and Voorhees and Mr Kang) and the Departments of Internal Medicine and Surgery (Dr Vinik), University of Michigan Medical Center, Ann Arbor; the Dermatology Service, Veterans Administration Medical Center, Ann Arbor (Drs Ellis, Grekin, and Voorhees); and the Department of Clinical Research, Hoffmann-La Roche Inc, Nutley, NJ (Dr Cunningham).

Footnotes
Accepted for publication Nov 19, 1986.

Presented in part at the summer session of the American Academy of Dermatology, San Diego, June 21, 1985.

Reprint requests to Department of Dermatology, University of Michigan Medical Center, Room 1910L Taubman Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0314 (Dr Ellis).

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