The Anticardiolipin Syndrome: A New Way to Slice an Old Pie, or a New Pie to Slice?

doi:10.1001/archderm.1987.01660290058016

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Vol. 123 No. 5, May 1987

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The Anticardiolipin Syndrome

A New Way to Slice an Old Pie, or a New Pie to Slice?

Richard D. Sontheimer, MD

Arch Dermatol. 1987;123(5):590-595.

Abstract

• Students of systemic lupus erythematosus have long beenconfused by the paradoxical association of atypical clinicalfeatures such as recurrent thrombosis and spontaneous abortionwith the lupus anticoagulant and biologic false-positive VDRLreaction. The recent development of sensitive, solid-phase immunoassaysfor quantitating the autoantibody response to phospholipidsholds the promise of illuminating the basis for this seemingenigma. It is now apparent that antiphospholipid antibodiessuch as anticardiolipin might well play a role in mediatingthe elements of this paradox. In addition, other cutaneous vascularconditions as diverse as livedo reticularis and Degos' diseasemight also be related to this type of autoimmune response.

(Arch Dermatol 1987;123:590-595)

Author Affiliations

From the Department of Dermatology, University of Texas Health Science Center at Dallas.

Footnotes

Accepted for publication Jan 19, 1987.

Reprint requests to Department of Dermatology, University ofTexas Health Science Center at Dallas, 5323 Harry Hines Blvd,Dallas, TX 75235 (Dr Sontheimer).

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