Prognostic Significance of Hypopigmentation in Malignant Melanoma

doi:10.1001/archderm.1987.01660320095019

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Vol. 123 No. 8, August 1987

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Prognostic Significance of Hypopigmentation in Malignant Melanoma

Jean-Claude Bystryn, MD; Darrell Rigel, MD; Robert J. Friedman, MD; Alfred Kopf, MD

Arch Dermatol. 1987;123(8):1053-1055.

Abstract

• It has been suggested that the presence of cutaneoushypopigmentation favorably influences the prognosis of patientswith malignant melanoma (MM). To examine this possibility, wehave compared the actual with the predicted survival of 46 patientswith MM and hypopigmentation who were among 1130 patients withMM entered in a long-term prospective study of MM at the NewYork University Medical Center. The actual average five-yearsurvival rate of the patients with MM and hypopigmentation (86.3%)was significantly better than predicted (74.8%) on the basisof the risk factors present in each patient at the time of entryinto the study. The findings suggest that hypopigmentation isa factor that beneficially influences the prognosis of MM, andthat the mechanisms that inhibit or destroy normal melanocytesin patients with MM may also slow the growth of this cancer.

(Arch Dermatol 1987;123:1053-1055)

Author Affiliations

From the Department of Dermatology and the Kaplan Cancer Center, New York University School of Medicine.

Footnotes

Accepted for publication Jan 30, 1987.

Reprint requests to the Department of Dermatology, New YorkUniversity School of Medicine, 560 First Ave, New York, NY 10016(Dr Bystryn).

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