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Jean-Claude Roujeau, MD; Thien Nhan Huynh, MD; Christine Bracq, MD; Jean-Claude Guillaume, MD; Jean Revuz, MD; René Touraine, MD

Arch Dermatol. 1987;123(9):1171-1173.

Abstract
• The pathophysiologic events leading to toxic epidermal necrolysis (TEN) remain unknown. With the idea of an immunologically mediated reaction occurring in predisposed subjects we performed HLA-A, -B and -DR typing in 44 patients surviving TEN. We observed a significant increase of only HLA-B12, previously found associated with ocular complications of Stevens-Johnson syndrome. When patients were stratified according to the drugs involved as causes for their TEN, we found other HLA phenotypes associated with B12, varying with each category of drugs. Sulfonamide-related cases of TEN were linked to A29, B12, and DR7, while oxicam-related cases of TEN were linked to A2 and B12. These results suggest that a genetic background, related to the major histocompatibility complex, may contribute to severe blistering drug reactions.

(Arch Dermatol 1987;123:1171-1173)

Author Affiliations
From the Service de Dermatologie and the Centre Départemental de Transfusion Sanguine, Hôpital Henri Mondor, Université Paris Val-de-Marne, 94010 Créteil, France.

Footnotes
Accepted for publication May 22, 1987.

Presented in part at the annual meeting of the European Society for Dermatological Research, Amsterdam, May 1985.

Reprint requests to the Service de Dermatologie, Hôpital Henri Mondor, 94010 Créteil, France (Dr Roujeau).

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