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John T. Headington, MD; Mark S. Roth, MD; David Ginsburg, MD; Allen S. Lichter, MD; Dan Hyder, MD; Bertram Schnitzer, MD

Arch Dermatol. 1987;123(9):1183-1187.

Abstract
A case of regressing atypical histiocytosis having characteristic clinical and light microscopic findings was studied immunologically for immunoglobulin and T-cell receptor gene rearrangement and for DNA ploidy analysis. Immunologic phenotyping and rearrangement of T-cell receptor β- and -chain genes indicated that this primary cutaneous neoplasm, previously considered "histiocytic" in origin, is most probably of T-cell lineage.

(Arch Dermatol 1987;123:1183-1187)

Author Affiliations
From the Departments of Pathology (Drs Headington and Schnitzer), Medicine (Drs Roth and Ginsburg), and Radiation Therapy (Dr Lichter), University of Michigan Medical School, Ann Arbor; and the Department of Pathology, Good Samaritan Hospital Medical Center, Portland, Ore (Dr Hyder). Dr Ginsburg is a Howard Hughes Medical Institute investigator.

Footnotes
Accepted for publication March 23, 1987.

Reprint requests to Department of Pathology, University of Michigan Medical School, Medical Sciences I, Suite M5242,1500 E Medical Center Dr, Ann Arbor, MI 48109-0602 (Dr Headington).

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