 |
|
Association of Progressive Systemic Scleroderma to Several HLA-B and HLA-DR Alleles
Christoph Luderschmidt, MD;
Siegfried Scholz, MD;
Elisabeth Mehlhaff, MD;
Gerhard König, MD;
Ekkehard Albert, MD
Arch Dermatol. 1987;123(9):1188-1191.
Abstract
• The HLA-A, B, C, and DR loci of 136 patients with progressive systemic scleroderma have been determined. The patients were classified according to the extent of their skin affection and into groups with or without immunologic and inflammatory signs of the disease. The antigens of the A locus did not show any significant deviations in frequency of occurrence. An increase of HLA-B8 and HLA-DR3 was only proved in the male patient group. Furthermore, in the HLA-DR gene locus, an increase in frequency of HLA-DR1, 2, 3, and 5 could be found. However, in the total set of patients, only the correlation of HLA-DR5 with progressive systemic scleroderma reached significance. Patients suffering from the CREST (calcinosis, Raynaud's phenomenon, esophagus, sclerodactyly, and telangiectasia) syndrome showed an increase of HLA-DR1. Patients with inflammatory signs of the scleroderma showed an accumulation of HLA-DR2. Several HLA-linked genes control the susceptibility to scleroderma.
(Arch Dermatol 1987;123:1188-1191)
Author Affiliations
From the Dermatological Clinic and Polyclinic of the Rheinische Friedrich-Wilhelms University, Bonn, West Germany (Dr Luderschmidt); the Laboratory for Immunogenetics of the Polyclinic of the Ludwig-Maximilian University (Drs Scholz, Mehlhaff, and Albert), and the Pneumonological Department of the Medical Clinic I Klinikum Grosshadern of the Ludwig-Maximilian University (Dr König), Munich.
Footnotes
Accepted for publication Feb 20, 1987.
Reprint requests to Residenzstrasse 27, D-8000 Munich, West Germany (Dr Luderschmidt).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
HLA allelic variants encoding DR11 in diffuse and limited systemic sclerosis in Caucasian women
Loubiere et al.
Rheumatology (Oxford) 2005;44:318-322.
ABSTRACT
| FULL TEXT
Systemic scleroderma in Greece: low mortality and strong linkage with HLA-DRB1*1104 allele
Vlachoyiannopoulos et al.
Ann Rheum Dis 2000;59:359-367.
ABSTRACT
| FULL TEXT
|
