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Takuo Tsuji, MD; Yasusada Imajo, MD; Motokazu Sawabe, MD; Shuichi Kuniyuki, MD; Masamitsu Ishii, MD; Toshio Hamada, MD; Eiji Ishimura, MD; Noboru Hamada, MD; Yoshiki Nishisawa, MD; Hirotoshi Morii, MD

Arch Dermatol. 1987;123(9):1211-1216.

Abstract
• A 41-year-old woman developed laxity and wrinkling of the skin. This process spread slowly to involve the skin of almost the entire body, without any previous inflammatory skin disorder. The skin of her face, neck, and trunk hung in loose folds, leading to a prematurely aged appearance. One year later she noticed edema on her face and legs. Laboratory studies disclosed low C3 and CH50 serum levels and proteinuria. Skin biopsy specimens revealed extensive loss and fragmentation of dermal elastic fibers. A renal biopsy specimen showed membranoproliferative glomerulonephritis (type 2), and an immunofluorescent study disclosed C3 and IgG deposition in the mesangial matrix and along the glomerular basement membrane. We propose that, in this case, cutis laxa may be related to an abnormal immune response.

(Arch Dermatol 1987;123:1211-1216)

Author Affiliations
From the Department of Dermatology (Drs Tsuji, Sawabe, Kuniyuki, Ishii, and T. Hamada) and the Second Department of Internal Medicine (Drs Imajo, Ishimura, N. Hamada, Nishisawa, and Morii), Osaka (Japan) City University Medical School.

Footnotes
Accepted for publication April 29, 1987.

Reprint requests to Department of Dermatology, Osaka City University Medical School, 1-5-7 Asahimachi, Abeno, Osaka 545, Japan (Dr Tsuji).

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