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A Histologic, Immunocytochemical, and Ultrastructural Study of Two Patients

Thomas Bieber, MD; Thomas Ruzicka, MD; Reinhold P. Linke, MD; Renate von Kries, MD; Günter Goerz, MD; Otto Braun-Falco, MD

Arch Dermatol. 1988;124(11):1683-1686.

Abstract
• In patients with bullous hemorrhagic amyloidosis of the skin, the skin lesions were the first manifestations of a plasma cell dyscrasia. Both cases were characterized by similar clinical, histologic, and ultrastructural findings showing an intradermal blister within deposits of amyloid substances. Immunohistologic investigations with a panel of antibodies directed against amyloid fibril proteins showed reactivity of the amyloid deposits with an anti-A X serum in both patients.

(Arch Dermatol 1988;124:1683-1686)

Author Affiliations
From the Departments of Dermatology (Drs Bieber, Ruzicka, and Braun-Falco) and Immunology (Dr Linke), Ludwig-Maximilians University, Munich; and the Department of Dermatology, University of Düsseldorf (Drs von Kries and Goerz), West Germany.

Footnotes
Accepted for publication May 27, 1988.

Reprint requests to Department of Dermatology, Ludwig-Maximilians University, Frauenlobstrasse, 9-11, 8000 Munich 2, West Germany (Dr Bieber).

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