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A Preliminary Study

Lois Y. Matsuoka, MD; Jacobo Wortsman, MD; Nancy Hanifan; Michael F. Holick, MD, PhD

Arch Dermatol. 1988;124(12):1802-1804.

Abstract
• Sunscreens block the absorption of the sunlight spectrum responsible for the cutaneous synthesis of vitamin D (ultraviolet B). The present study was prompted by our observation of suppression of cutaneous vitamin D formation by a single application of sunscreening agents. We measured the index of vitamin D body store, serum 25-hydroxyvitamin D (25-OH-D) level, in 20 long-term users of p-aminobenzoic acid (PABA) and in 20 controls matched by age and exposure to sunlight. Serum 25-OH-D levels were significantly lower among long-term PABA users than among normal controls: 40.2 ± 3.2 vs 91.3 ± 6.2 nmol/L. Furthermore, vitamin D deficiency, ie, 25-OH-D levels below 20.0 nmol/L, was seen in two PABA users and in none of the controls. This preliminary study suggests that long-term use of PABA may be associated with low body stores of vitamin D in some persons.

(Arch Dermatol 1988;124:1802-1804)

Author Affiliations
From the Department of Dermatology, Jefferson Medical College, Philadelphia (Dr Matsuoka); and the Departments of Medicine, Southern Illinois University School of Medicine, Springfield (Dr Wortsman), and Boston University School of Medicine (Ms Hanifan and Dr Holick).

Footnotes
Accepted for publication April 21, 1988.

Reprint requests to Department of Dermatology, Jefferson Medical College, 111 S 11th St, Philadelphia, PA 19107 (Dr Matsuoka).

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