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Possible Involvement of Interferon Alfa

Tetsuo Shiohara, MD; Masaru Kobayashi, MD; Kimiaki Abe, MD; Masaji Nagashima, MD

Arch Dermatol. 1988;124(12):1816-1821.

Abstract
• We describe a patient who developed psoriasis predominantly on the lesions of warts. After therapy with etretinate, all psoriatic lesions resolved completely, leaving only the warts. An intralesional injection of interferon alfa resulted in the rapid development of psoriatic lesions on the warts located on the dorsal aspect of the hand, as they were before therapy was started. Two injections with interferon alfa induced onset of psoriasis on warts located on the wrist. Psoriasis had not developed in this location previously. Interferon alfa may play an important role in the development of psoriasis.

(Arch Dermatol 1988;124:1816-1821)

Author Affiliations
From the Department of Dermatology, Kyorin University School of Medicine, Tokyo. Dr Abe is now in private practice, Tokyo.

Footnotes
Accepted for publication March 29, 1988.

Reprint requests to Department of Dermatology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181, Japan (Dr Shiohara).

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