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Pierre Y. Venencie, MD; Georges A. Boffa, MD; Pierre D. Delmas, MD, PhD; Olivier Verola, MD; Ismaïl Benkaïdali, MD; Jacques Frija, MD; Bernard Pillet, MD; Antoine Puissant, MD

Arch Dermatol. 1988;124(12):1831-1834.

Abstract
• We evaluated a patient in whom pachydermoperiostosis occurred in conjunction with anemia and gastric hypertrophy. The mechanism of the anemia appears multifactorial because, besides a myelofibrosis, a serum inhibitor of the late stage of erythropoiesis was detected. The elevated serum bone Gla-protein (osteocalcin) favors the hypothesis that primary hypertrophic osteoarthropathy represents an imbalance between increased osteoblastic bone formation and normal bone resorption.

(Arch Dermatol 1988;124:1831-1834)

Author Affiliations
From Unité de Dermatologie, Centre Hospitalier Universitaire, Bicêtre, France (Dr Venencie); Institut National de Transfusion Sanguine (Dr Boffa), and Départements d'Anatomie Pathologique (Dr Verola), de Radiologie (Dr Frija), de Médecine Interne (Dr Pillet), and Clinique Dermatologique (Dr Puissant), Hôpital Saint-Louis, Paris; Unité INSERM 234, Hôpital E. Herriot, Lyon, France (Dr Delmas); and Service de Dermatologie, Hôpital Mustapha, Algiers, Algeria (Dr Benkaïdali).

Footnotes
Accepted for publication June 8, 1988.

Read in part before the annual meeting of the American Academy of Dermatology, New Orleans, Dec 6, 1986; and before the International Congress of Dermatology, Berlin, May 27, 1987.

Reprint requests to Unité de Dermatologie, CHU Bicêtre, 78, rue du Général Leclerc, 94275 Le Kremlin Bicêtre Cedex, France (Dr Venencie).

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