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Potential Roles of Fibronectin in Cutaneous Wound Repair
Richard A. F. Clark, MD
Arch Dermatol. 1988;124(2):201-206.
Abstract
• Fibronectin has many potential roles in wound repair, including chemotactic factor activity for monocytes, fibroblasts, and endothelial cells; opsonin activity and opsonin promoter activity for microorganism and tissue debris; substratum for cell migration and localization; and a scaffold for building extracellular matrix. Although fibronectin has been reported to have intrinsic growth-promoting ability, coisolation of authentic growth factors with fibronectin raises doubts about this observation. Whether the addition of exogenous fibronectin to wounds can augment healing is a question for future studies.
(Arch Dermatol 1988;124:201-206)
Author Affiliations
From the Dermatology Program, National Jewish Center for Immunology and Respiratory Medicine, Denver.
Footnotes
Accepted for publication Aug 20, 1987.
Reprint requests to the Dermatology Program, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson St, Denver, CO 80206 (Dr Clark).
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