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Therapeutic Relevance

Thomas D. Griffin, MD; Anand Lattanand, MD; Eugene J. VanScott, MD

Arch Dermatol. 1988;124(2):216-220.

Abstract
• Twenty-three patients with resistant psoriasis vulgaris were evaluated clinically and histologically before and after treatment with potent topically administered steroids. It was shown that psoriatic plaques are comprised of clinically and histologically distinct acute and chronic areas, each responding differently to treatment. Chronic areas, characterized by chronic inflammation, respond well to therapy; acute areas, characterized by acute inflammation, are resistant to therapy. It is suggested that the psoriagenic stimulus is greater within the therapy-resistant "hot spots." Future therapy aimed at hot spots may aid in the better control of psoriasis.

(Arch Dermatol 1988;124:216-220)

Author Affiliations
From the Skin and Cancer Hospital, Temple University Health Sciences Center, Philadelphia.

Footnotes
Accepted for publication Sept 17,1987.

Presented as a poster at the 45th annual meeting of the American Academy of Dermatology, New Orleans, Dec 6-11, 1986.

Reprint requests to Skin and Cancer Hospital, Temple University Health Sciences Center, 3322 N Broad St, Philadelphia, PA 19140 (Dr Griffin).

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