 |
|
Poikilodermatous Mycosis Fungoides and Atrophic Large-Plaque Parapsoriasis Exhibit Similar Abnormalities of T-Cell Antigen Expression
Mary L. Lindae, MD;
Elizabeth A. Abel, MD;
Richard T. Hoppe, MD;
Gary S. Wood, MD
Arch Dermatol. 1988;124(3):366-372.
Abstract
• We studied the immunohistologic findings of skin biopsy specimens from 21 patients with poikiloderma (14 with mycosis fungoides [MF] and seven with atrophic large-plaque parapsoriasis [ALPP]). Both types of poikiloderma were similar with regard to T-cell antigen expression. In each case, most T cells expressed the CD4+ (helper/inducer) phenotype and lacked Leu-8 antigen. T cells were also deficient in Leu-9 antigen in most cases (MF, 11/14 [79%]; ALPP, 4/7 [57%]). These T-cell antigen deficiencies are similar to those described previously in various types of MF and indicate that such deficiencies are common in minimally infiltrated, patch-stage MF lesions. Because combined Leu-8/Leu-9 antigen deficiencies are uncommon in inflammatory skin diseases, our findings are consistent with the view that ALPP is an early form of MF, as had been suggested previously by results of clinicopathologic studies.
(Arch Dermatol 1988;124:366-372)
Author Affiliations
From the Departments of Dermatology (Drs Lindae, Abel, and Wood), Pathology (Dr Wood), and Therapeutic Radiology (Dr Hoppe), Stanford (Calif) University Medical Center, and the Veterans Administration Medical Center, Palo Alto, Calif (Dr Wood).
Footnotes
Accepted for publication Sept 2, 1987.
Reprints not available.
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Immunophenotypic Correlation Between Skin Biopsy and Peripheral Blood Findings in Mycosis Fungoides
Kelemen et al.
Am J Clin Pathol 2010;134:739-748.
ABSTRACT
| FULL TEXT
Demonstration of Frequent Occurrence of Clonal T Cells in the Peripheral Blood But Not in the Skin of Patients With Small Plaque Parapsoriasis
Muche et al.
Blood 1999;94:1409-1417.
ABSTRACT
| FULL TEXT
|
