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A Unique Clinical Feature With Monoclonal T-Cell Proliferation Detected by Southern Blot Analysis

Kenzo Takahashi, MD; Toshihiro Tanaka, MD; Mayumi Fujita, MD; Yuji Horiguchi, MD; Yoshiki Miyachi, MD; Sadao Imamura, MD

Arch Dermatol. 1988;124(3):399-404.

Abstract
• A 60-year-old woman suffered from multiple subcutaneous nodules with a self-limited clinical course. High titer of the antibody against the adult T-cell leukemia/ lymphoma (ATL)-associated cell antigen was detected and atypical lymphocytes were present in less than 1% of the peripheral leukocytes. Tumor cells were identified by the molecular biology technique Southern blot analysis, which showed monoclonal cell expansion of the helper/ inducer T cells integrated with human T-cell lymphotropic virus type I/adult T-cell leukemia virus. This patient was diagnosed as having the cutaneous type of smoldering ATL in a very early stage. In this case, only gene analysis of the skin lesion could facilitate making an early differential diagnosis of ATL from other lymphoproliferative diseases, including nonviral cutaneous T-cell lymphoma and benign lymphoid hyperplasia.

(Arch Dermatol 1988;124:399-404)

Author Affiliations
From the Department of Dermatology, Faculty of Medicine, Kyoto (Japan) University.

Footnotes
Accepted for publication Sept 9, 1987.

Reprint requests to the Department of Dermatology, Faculty of Medicine, Kyoto University, Shogoin, Sakyo-ku, Kyoto 606, Japan (Dr Takahashi).

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