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Thrombocytopenia in the Neonatal Lupus Syndrome
Rosemarie Watson, MD;
J. Elica Kang, MD;
Michael May, MD;
Mark Hudak, MD;
Thomas Kickler, MD;
Thomas T. Provost, MD
Arch Dermatol. 1988;124(4):560-563.
Abstract
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• Thrombocytopenia has been documented infrequently in association with congenital heart block or lupus dermatitis in the neonatal lupus erythematosus syndrome. We report the cases of two infants with transient neonatal thrombocytopenia born to mothers with connective-tissue disease. Both mother/infant pairs were Ro(SS-A) antibody positive. Although the finding of neonatal thrombocytopenia in the presence of maternal connective-tissue disease suggests an autoimmune thrombocytopenia, platelet antibody studies were negative in both mother/infant pairs. We have found the Ro (SS-A) antibody with increased frequency in idiopathic thrombocytopenic purpura and thrombocytopenia associated with Sjögren's syndrome, but the nature of the association is unknown. We suggest that thrombocytopenia in our patients is a manifestation of the neonatal lupus erythematosus syndrome. This syndrome should be included in the differential diagnosis of neonatal thrombocytopenia.
(Arch Dermatol 1988;124:560-563)
Author Affiliations
From the Departments of Dermatology (Drs Watson and Provost), Pediatrics (Drs May, Kang, and Hudak), and Laboratory Medicine and Medicine (Dr Kickler), The Johns Hopkins Medical Institutions, Baltimore.
Footnotes
Accepted for publication Sept 17, 1987.
Read before the Eastern Section of the Society of International Dermatology, New York, Oct 11, 1986.
Reprints not available.
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