 |
|
Acute Follicular Graft-vs-Host ReactionA Distinct Clinicopathologic Presentation
Kenneth J. Friedman, MD;
Philip E. LeBoit, MD;
Evan R. Farmer, MD
Arch Dermatol. 1988;124(5):688-691.
Abstract
• Human graft-vs-host disease (GVHD) is a life-threatening complication that may occur following allogeneic bone marrow transplantation. In acute GVHD, skin involvement is frequent, and the skin is often the initial organ involved. The rash typically is a blanchable, erythematous macular eruption. We present the first report of follicular cutaneous GVHD. Three patients developed follicular papules simulating bacterial or fungal folliculitis as a major clinical expression of cutaneous involvement in acute GVHD following allogeneic bone marrow transplantation. In each case, histopathologic examination demonstrated features of acute graft-vs-host reaction involving hair follicles. This suggests that follicular epithelium may be an early target in acute GVHD.
(Arch Dermatol 1988;124:688-691)
Author Affiliations
From the Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore (Drs Friedman and Farmer); and the Departments of Dermatology and Pathology, University of California School of Medicine at San Francisco (Dr LeBoit).
Footnotes
Accepted for publication Dec 17, 1987.
Reprint requests to Department of Dermatology, Johns Hopkins Medical Institutions, 600 N Wolfe St, Baltimore, MD 21205 (Dr Friedman).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Atypical Early Follicular Graft-vs-Host Disease.
Goiriz et al.
Arch Dermatol 2006;142:1237-1238.
FULL TEXT
Cutaneous Graft-versus-Host Disease
Aractingi and Chosidow
Arch Dermatol 1998;134:602-612.
ABSTRACT
| FULL TEXT
Acute Follicular Graft-vs-Host Disease
Lycka and Kaye
Arch Dermatol 1988;124:1442-1442.
ABSTRACT
|
