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Vol. 124 No. 5, May 1988 |
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PATHOGENESIS, CLINICAL FEATURES AND MANAGEMENT OF THE NON-DERMATOLOGICAL COMPLICATIONS OF EPIDERMOLYSIS BULLOSA |
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The Extracellular Matrix Is a Soluble and Solid-Phase Agonist and Receptor
Robert L. Trelstad, MD
Arch Dermatol. 1988;124(5):706-708.
Abstract
• The components of the extracellular space have well-recognized structural functions. The role of the matrix as a conduit and/or repository for signals, however, has received much less attention. Because we know that cells require contact with the extracellular matrix for their normal function, that intact matrix and/or fragments of matrix in either soluble or solid phase can effect significant changes in cellular physiology, and that matrix components can be integral membrane proteins, we conclude that a major function of the matrix is as a soluble and solid-phase agonist and receptor.
(Arch Dermatol 1988;124:706-708)
Author Affiliations
From the Department of Pathology, Robert Wood Johnson Medical School, Piscataway, NJ.
Footnotes
Accepted for publication Sept 14, 1987.
Presented in part at the workshop on the Pathogenesis, Clinical Features, and Management of the Non-Dermatological Complications of Epidermolysis Bullosa, National Institutes of Health, Bethesda, Md, Sept 8, 1986.
Reprint requests to the Department of Pathology, Robert Wood Johnson Medical School, Piscataway, NJ 08854 (Dr Trelstad).
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