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Eugene A. Bauer, MD; Maxine Tabas, MD

Arch Dermatol. 1988;124(5):734-736.

Abstract
• The pathophysiology of tissue fragility in recessive dystrophic epidermolysis bullosa may be due in part to excessive destruction of interstitial collagens by a structurally altered, but catalytically active, form of human skin collagenase. Therapeutic attempts directed toward reducing the expression of this enzyme have resulted in clinical improvement in some patients with the disease.

(Arch Dermatol 1988;124:734-736)

Author Affiliations
From the Division of Dermatology, Department of Medicine, and the Washington/Dystrophic Epidermolysis Bullosa Research Association Center for Research and Therapy of Epidermolysis Bullosa, Washington University School of Medicine, St Louis.

Footnotes
Accepted for publication Sept 14, 1987.

Presented in part at the workshop on the Pathogenesis, Clinical Features, and Management of the Non-Dermatological Complications of Epidermolysis Bullosa, National Institutes of Health, Bethesda, Md, Sept 8, 1986.

Reprint requests to the Division of Dermatology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 (Dr Bauer).

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