Tissue Stress and Tumor Promotion: Possible Relevance to Epidermolysis Bullosa

doi:10.1001/archderm.1988.01670050081027

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Vol. 124 No. 5, May 1988

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PATHOGENESIS, CLINICAL FEATURES AND MANAGEMENT OF THE NON-DERMATOLOGICAL COMPLICATIONS OF EPIDERMOLYSIS BULLOSA

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Tissue Stress and Tumor Promotion

Possible Relevance to Epidermolysis Bullosa

Gregory I. Goldberg, PhD; Arthur Z. Eisen, MD; Eugene A. Bauer, MD

Arch Dermatol. 1988;124(5):737-741.

Abstract

• Cutaneous carcinomas often arise in patients with severeepidermolysis bullosa (or other cutaneous ulcers) at multipleprimary sites. Chronic tissue stress thus appears to promotecarcinogenesis in preexisting somatic mutants in a stem cellpopulation. Altered contractile properties of fibroblasts culturedfrom skin with epidermolysis bullosa may result from an alteredinteraction of these cells with their surrounding, chronicallystressed, connective tissue matrix.

(Arch Dermatol 1988;124:737-741)

Author Affiliations

From the Division of Dermatology, Washington University School of Medicine, St Louis.

Footnotes

Accepted for publication Sept 14, 1987.

Presented in part at the Workshop on the Pathogenesis, ClinicalFeatures, and Management of the Non-Dermatological Complicationsof Epidermolysis Bullosa, National Institutes of Health, Bethesda,Md, Sept 8, 1986.

Reprint requests to the Division of Dermatology, WashingtonUniversity School of Medicine, 660 Euclid Ave, St Louis, MO63110 (Dr Goldberg).

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