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Possible Relevance to Epidermolysis Bullosa

Gregory I. Goldberg, PhD; Arthur Z. Eisen, MD; Eugene A. Bauer, MD

Arch Dermatol. 1988;124(5):737-741.

Abstract
• Cutaneous carcinomas often arise in patients with severe epidermolysis bullosa (or other cutaneous ulcers) at multiple primary sites. Chronic tissue stress thus appears to promote carcinogenesis in preexisting somatic mutants in a stem cell population. Altered contractile properties of fibroblasts cultured from skin with epidermolysis bullosa may result from an altered interaction of these cells with their surrounding, chronically stressed, connective tissue matrix.

(Arch Dermatol 1988;124:737-741)

Author Affiliations
From the Division of Dermatology, Washington University School of Medicine, St Louis.

Footnotes
Accepted for publication Sept 14, 1987.

Presented in part at the Workshop on the Pathogenesis, Clinical Features, and Management of the Non-Dermatological Complications of Epidermolysis Bullosa, National Institutes of Health, Bethesda, Md, Sept 8, 1986.

Reprint requests to the Division of Dermatology, Washington University School of Medicine, 660 Euclid Ave, St Louis, MO 63110 (Dr Goldberg).

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