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Hidradenitis SuppurativaGlucose Tolerance, Clinical, Microbiologic, and Immunologic Features and HLA Frequencies in 27 Patients
Sean O'Loughlin, MB, FRCPI;
Robert Woods, MPhil, CBiol, MIBiol, FIMLS;
Peadar N. Kirke, FFCMI, FFCM, MSc, DCH, DObst;
Fergus Shanahan, MRCP;
Anne Byrne, FIMLS;
Michael Ivor Drury, MD, DSc, FRCPI, FRCOG
Arch Dermatol. 1988;124(7):1043-1046.
Abstract
• Glucose tolerance, lymphocyte populations, and HLA types were studied in 27 patients with untreated hidradenitis suppurativa; 18 of these patients had a negative history for acne vulgaris. Six patients (22%) had an increased incidence of impaired glucose tolerance. We failed to confirm a previous report of high incidence of flat glucose tolerance curves. The frequency of HLA-A and HLA-B antigen loci and the median values of peripheral blood T lymphocytes were similar to the control population. However, seven patients with moderate or severe clinical disease had a marked reduction in T lymphocytes and these patients had an increased frequency of the HLA antigens, A1 and B8. These results suggest that T lymphocytes may play a role in the pathogenesis of hidradenitis suppurativa and that HLA-A1 and HLA-B8 may predispose the patient to more severe disease, but further research is necessary to clarify this.
(Arch Dermatol 1988;124:1043-1046)
Author Affiliations
From the Departments of Dermatology (Dr O'Loughlin), Immunology (Mr Woods and Ms Byrne), and Endocrinology (Drs Shanahan and Drury), Mater Misericordiae Hospital, and the Medico-Social Research Board (Dr Kirke), Dublin.
Footnotes
Accepted for publication Oct 20, 1987.
Reprint requests to Mater Misericordiae Hospital, Eccles Street, Dublin 7, Ireland (Dr O'Loughlin).
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