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Hiroshi Shimizu, MD; Takehiko Komatsu, MD; Takashi Harada, MD; Takeji Nishikawa, MD; Sayumi Tsuzaki, MD; Atsuo Mikata, MD

Arch Dermatol. 1988;124(8):1254-1257.

Abstract
• An immunohistochemical and ultrastructural study of an atypical case of multiple non-X histiocytoma was done. There was involvement of the skin, lungs, and liver in a 3-month-old male infant. Microscopic examination of the cutaneous tumors revealed a dense infiltration of cells with polymorphous large nuclei and abundant eosin-ophilic cytoplasm in the entire dermis. Both immunohistochemical and electron microscopic studies suggested that the tumors were non-X histiocytomas. The patient's condition deteriorated with dyspnea due to rapid enlargement of tumor masses in the liver and lungs. However, at 5 months of age, the cutaneous nodules and pulmonary and hepatic lesions showed a tendency to involute. Furthermore, at 12 months of age, they were no longer detectable. The patient at 24 months of age was well with normal development. To date, no recurrence of the disease has been observed.

(Arch Dermatol 1988;124:1254-1257)

Author Affiliations
From the Departments of Dermatology (Drs Shimizu, Komatsu, Harada, and Nishikawa), Pediatrics (Dr Tsuzaki), and Pathology (Dr Mikata), Keio University School of Medicine, Tokyo.

Footnotes
Accepted for publication Jan 13, 1988.

Reprint requests to Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi Shinjaku, Tokyo 160, Japan (Dr Shimizu).

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