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Identification of Plasmacytoid T Cells in Lymphoid Hyperplasia of the Skin
Fritjof Eckert, MD;
Ulrico Schmid, MD
Arch Dermatol. 1989;125(11):1518-1524.
Abstract
• Well-defined clusters of plasmacytoid T cells were identified in two cases of lymphoid hyperplasia of the skin. With the use of paraffin-embedded and frozen sections and 46 different antibodies, the antigenic profile of plasmacytoid T cells was obtained. Corresponding to plasmacytoid T cells in reactive and neoplastic lymph node conditions, plasmacytoid T cells of the skin were devoid of most T-cell-restricted differentiation antigens CD2, CD3, CD5, and CD8 while expressing monocyte/macrophage-related antigens recognized by Ki-M6 and Ki-M7. In addition, plasmacytoid T cells were positive for CD4, CD45, HLA class II antigens (HLA-DR, Leu-10, MB3, LN2, LN3) and the transferrin receptor. Furthermore, they reacted with anti-Leu-8, MB1, Ki-B3 (CD45R), and MT1. Thus plasmacytoid T cells are considered to be mononuclear cells with monocyte/macrophage differentiation rather than T lymphocytes. In addition, our findings substantiate the concept that plasmacytoid T cells may function as a hitherto unrecognized subgroup of antigen-presenting cells in the skin.
(Arch Dermatol. 1989;125:1518-1524)
Author Affiliations
From the Department of Dermatology, University of Munich, West Germany (Dr Eckert), and the Department of Pathology, Kantonsspital St Gallen (Switzerland) (Dr Schmid).
Footnotes
Accepted for publication June 22, 1989.
Reprint requests to Department of Dermatology, University of Munich, Frauenlobstrasse 9-11,8000 Munich 2, West Germany (Dr Eckert).
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