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A Light Microscopic and Immunohistochemical Study

Ronald J. Barr, MD; Daniel J. Santa Cruz, MD; Robert M. Pearl, MD

Arch Dermatol. 1989;125(12):1681-1684.

Abstract
• Two rare cases of distinctive thymic remnants occurring in the skin are described. The lesions were present at birth, and involved the side of the neck. One child had a complete cleft lip and palate. The other had multiple congenital anomalies consistent with a rare syndrome entitled branchio-oculo-facialsyndrome. Microscopically, lobular foci were present in the dermis and consistent with both prethymic and thymic remnants. Immunohistochemical studies using antibodies to T cells and B cells showed a distribution similar to that seen in normal thymus. Dermal thymus appears to be a distinct entity and may be associated with other faciobranchial defects.

(Arch Dermatol. 1989;125:1681-1684)

Author Affiliations
From the Dermatopathology Laboratory, Department of Dermatology, University of California Irvine Medical Center (Dr Barr); the Department of Pathology, St John's Mercy Medical Center, St Louis, Mo (Dr Santa Cruz); and The Permanente Medical Group Inc, Santa Clara, Calif (Dr Pearl).

Footnotes
Accepted for publication July 30, 1989.

Reprint requests to Dermatopathology Laboratory, University of California Irvine Medical Center, Rte 48,101 City Dr S, Orange, CA 92668 (Dr Barr).

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